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Título : | Leishmania braziliensis : partial control of experimental infection by Interleukin-12 p40 deficient mice. |
Autor : | Souza Neto, Sebastião Martins de Carneiro, Cláudia Martins Vieira, Leda Quercia Afonso, Luís Carlos Crocco |
Palabras clave : | Cutaneous leishmaniasis Leishmania braziliensis |
Fecha de publicación : | 2004 |
Citación : | SOUZA NETO, S. M. de et al. Leishmania braziliensis: partial control of experimental infection by Interleukin-12 p40 deficient mice. Memórias do Instituto Oswaldo Cruz, v. 99, p. 289-294, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n3/v99n3a09.pdf>. Acesso em: 21 out. 2015. |
Resumen : | Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-γ) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN-γ-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN-γ suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL- 12p40 -/- infected with L. braziliensis. |
URI : | http://www.repositorio.ufop.br/handle/123456789/6103 |
metadata.dc.identifier.doi: | http://dx.doi.org/10.1590/S0074-02762004000300009 |
ISSN : | 1678-8060 |
metadata.dc.rights.license: | Todo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Memórias do Instituto Oswaldo Cruz <http://www.scielo.br/scielo.php/script_sci_serial/pid_0074-0276/lng_pt/nrm_iso>. Acesso em: 19 ago. 2019. |
Aparece en las colecciones: | DEACL - Artigos publicados em periódicos |
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Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_LeishmaniaBraziliensisPartial.pdf | 51,03 kB | Adobe PDF | Visualizar/Abrir |
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