Por favor, use este identificador para citar o enlazar este ítem:
http://www.repositorio.ufop.br/jspui/handle/123456789/12214
Título : | Phytochemistry and antiplasmodial activity of Xylopia sericea leaves. |
Autor : | Gontijo, Douglas da Costa Nascimento, Maria Fernanda Alves do Brandão, Geraldo Célio Oliveira, Alaide Braga de |
Palabras clave : | Annonaceae Essential oil Dichloromethane extract Alkaloids Acetogenins |
Fecha de publicación : | 2019 |
Citación : | GONTIJO, D. C. et al. Phytochemistry and antiplasmodial activity of Xylopia sericea leaves. Natural Product Research, fev. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1577838>. Acesso em: 10 fev. 2020. |
Resumen : | Aiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass spectrometry, and were evaluated against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity to HepG2 cells. Low growth inhibition of P. falciparum as well as low cytotoxicity to HepG2 cells were observed for the essential oil. The leaves dichloromethane extract showed moderate growth inhibition of P. falciparum and low cytotoxicity to HepG2 cells. Bioguided chromatographic fractionation of this extract led to fractions with increased antiplasmodial activity from which liriodenine (IC50 6.1 ± 0.1 μg/mL, CC50 > 1000.0 μg/mL, SI > 164), an aporphine alkaloid, and an acetogenin-rich fraction containing mainly isomers of annomontacin and 4-deoxy-annomontacin (IC50 22.7 ± 1.9 µg/mL, CC50 336.1 ± 15.5 µg/mL, SI = 15) might be highlighted for their antiplasmodial activity. |
URI : | http://www.repositorio.ufop.br/handle/123456789/12214 |
metadata.dc.identifier.uri2: | https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1577838 |
metadata.dc.identifier.doi: | https://doi.org/10.1080/14786419.2019.1577838 |
ISSN : | 1478-6427 |
Aparece en las colecciones: | DEFAR - Artigos publicados em periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
ARTIGO_PhytochemistryAntiplasmodialActivity.pdf Restricted Access | 953,37 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.