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Título: | Treatment with distinct antibiotic classes causes different pulmonary outcomes on allergic airway inflammation associated with modulation of symbiotic microbiota. |
Autor(es): | Cavalcante, Gregório Grama Guimarães, Anna Gabriella Glauss, Camila Pereira Queiroz Pereira, Marcela Helena Gonçalves Dias, Angélica Samer Lallo Horta, Laila Sampaio Oliveira, Jamil Silvano de Cangussú, Silvia Dantas Magalhães, Paula Prazeres Russo, Remo de Castro Santiago, Helton da Costa |
Data do documento: | 2022 |
Referência: | CAVALCANTE, G. G. et al. Treatment with distinct antibiotic classes causes different pulmonary outcomes on allergic airway inflammation associated with modulation of symbiotic microbiota. Journal of Immunology Research, v. 2022, artigo 1466011, 2022. Disponível em: <https://www.hindawi.com/journals/jir/2022/1466011/>. Acesso em: 11 out. 2022. |
Resumo: | Background. Asthma is a chronic pulmonary disease that affects about 300 million people worldwide. Previous studies have associated antimicrobial use with allergies, but the real impact of antibiotics on asthma is still elusive. We investigated the potential impact of amoxicillin (Amox), trimethoprim/sulfamethoxazole (TMP/SMX), and metronidazole (Metro) in a murine model of OVA-induced allergic airway inflammation. Methods. BALB/c mice received three cycles of 7 days of antibiotics in drinking water followed by 7 days washout and were sensitized i.p. with OVA/Alum at days 0 and 14. After the end of the last antibiotic washout, the mice were challenged with aerosolized OVA. Pulmonary parameters were evaluated, and serum, BAL, and feces were collected for analysis. Results. Amox- and TMP/SMX-treated animals displayed more severe allergic airway inflammation parameters with increased airway hyperresponsiveness, reduced lung alveolar volume, and increased levels in BAL of IL-4 and IL-6. In contrast, Metro-treated mice showed preserved FEV-50, decreased lung inflammation, and higher levels of butyrate and propionate in their feces. Metro treatment was associated with increased OVA-specific IgA in serum. BAL microbiota was abundant in allergic groups but not in nonallergic controls with the Amox-treated group displaying the increased frequency of Proteobacteria, while Metro and TMP/SMX showed increased levels of Firmicutes. In the gut, we observed the enrichment of Akkermansia muciniphila associated with reduced airway inflammation phenotype in the Metro group, even after the recovery period. Conclusion. Our data suggest that different antibiotic treatments may impact the course of experimental allergic airway inflammation in diverse ways by several mechanisms, including modulation of short-chain fat acids production by intestinal microbiota. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/16564 |
DOI: | https://doi.org/10.1155/2022/1466011 |
ISSN: | 2314-7156 |
Licença: | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o PDF do artigo. |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_TreatmentDistinctAntibiotic.pdf | 2,16 MB | Adobe PDF | Visualizar/Abrir |
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