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Title: Antiedematogenic and antinociceptive effects of leaves extracts from Protium spruceanum Benth.
Authors: Rodrigues, Ivanildes Vasconcelos
Souza, Juliana Neves de Paula
Silva, Ana Cláudia G.
Chibli, Lucas Apolinário
Cabral, Vivette Appolinário Rodrigues
Vieira Filho, Sidney Augusto
Perazzo, Fábio Ferreira
Guimarães, Andrea Grabe
Souza, Gustavo Henrique Bianco de
Keywords: Burseraceae
Issue Date: 2013
Citation: RODRIGUES, I. V. et al. Antiedematogenic and antinociceptive effects of leaves extracts from Protium spruceanum Benth. Pharmacognosy Journal, v. 5, p. 6-12, 2013. Disponível em: <>. Acesso em: 10 out. 2017.
Abstract: Ethnopharmacological relevance: In traditional medicine, gums and oil-resins from Protium species have been used for many diseases, however, there are no reports of studies of Protium spruceanum’ leaves. Materials and methods: The antiedematogenic and antinociceptive effects of crude ethanol extract (EEB) from leaves of P. spruceanum and its fractions were evaluated in biological models. The fractions were obtained with hexane (FHEX) and methanol (FMEOH). Rat paw edema induced by carrageenan, writhing test, formalin test, hot plate test and the toxicity of EEB were performed. Results: Phytochemical analysis has shown the presence of a and b-amyrins as major constituents of FHEX. Promising results of anti-inflammatory and antinociceptive activity were found for EEB, FHEX and FMEOH. Also were observed the EEB at 6000 mg/kg showed no toxicity. Conclusions: One might suggest that the activities of FHEX are due to the presence of a and b-amyrins and contributes to the biological activities of EEB.
ISSN: 0975-3575
Appears in Collections:DEFAR - Artigos publicados em periódicos

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