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Title: Temporal analysis of oxidative effects on the pulmonary inflammatory response in mice exposed to cigarette smoke.
Authors: Campos, Keila Karine Duarte
Manso, Rafaela Gontijo
Gonçalves, Evandro Guedes
Silva, Marcelo Eustáquio
Lima, Wanderson Geraldo de
Menezes, Cristiane Alves da Silva
Bezerra, Frank Silva
Keywords: Cigarette smoke
Flow cytometry
Lung inflammation
Oxidative stress
Issue Date: 2013
Citation: CAMPOS, K. K. D. et al. Temporal analysis of oxidative effects on the pulmonary inflammatory response in mice exposed to cigarette smoke. Cellular Immunology, v. 284, p. 29-36, 2013. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: The most common factor related to the chronic obstructive pulmonary disease (COPD) development is the chronic smoking habit. Our study describes the temporal kinesis of pulmonary cellular influx through BALF analyses of mice acutely exposed to cigarette smoke (CS), the oxidative damage and antioxidative enzyme activities. Thirty-six mice (C57BL/6, 8 weeks old, male) were divided in 6 groups: the control group (CG), exposed to ambient air, and the other 30 mice were exposed to CS. Mice exposed to CS presented, especially after the third day of exposure, different cellular subpopulations in BALF. The oxidative damage was significantly higher in CS exposed groups compared to CG. Our data showed that the evaluated inflammatory cells, observed after three days of CS exposure, indicate that this time point could be relevant to studies focusing on these cellular subpopulation activities and confirm the oxidative stress even in a short term CS exposure.
ISSN: 0008-8749
metadata.dc.rights.license: O periódico Cellular Immunology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3520371206808.
Appears in Collections:DECBI - Artigos publicados em periódicos

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