Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.
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2009
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Introduction - Hypertension is closely associated with erectile dysfunction (ED) as it has been
observed in many experimental models of hypertension. Additionally, epidemiological studies
show that approximately a third of the hypertensive patients have ED.
Aim—To test the hypothesis that the two-kidney one-clip (2K-1C) rat model of hypertension
displays normal erectile function due to increased nitric oxide (NO) production in the penis.
Methods—Ganglionic-induced increase in intracavernosal pressure (ICP)/mean arterial pressure
(MAP) ratio was used as an index of erectile function in 2K-1C and in normotensive shamoperated
(SHAM) anesthetized rats. Cavernosal strips from hypertensive and normotensive rats
were used for isometric tension measurement. The contraction induced by alpha-adrenergic
agonist phenylephrine, and the relaxation induced by the nitric oxide (NO) donor sodium
nitroprusside (SNP) and by the Rho-kinase inhibitor Y-27632 were performed in the absence and
in the presence of the nitric oxide synthase (NOS) inhibitor L-NNA.
Results—Changes in ICP/MAP induced by ganglionic stimulation were not different between
2K-1C and SHAM rats. The contractile response induced by phenylephrine as well as the
relaxation induced by SNP or the Y-27632 were similar in cavernosal strips from both groups.
However, in the presence of L-NNA, the relaxation induced by Y-27632 was significantly
impaired in 2K-1C compared to SHAM).
Conclusions—These data suggest that hypertension and ED could be dissociated from high
levels of blood pressure in some animal models of hypertension. Erectile function in 2K-1C
hypertensive rats is maintained in spite of the increased Rho-kinase activity by increased NO
signaling.
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Rho-kinase
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LINDER, E. et al. Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production. The Journal of Sexual Medicine, v. 6, p. 279-285, 2009. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1743609515326801>. Acesso em: 10 jan. 2017.