Nitrotriazole-based compounds as antichagasic agents in a long-treatmenti In vivo assay.
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2017
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3-Nitrotriazole-based compounds belonging to various chemical subclasses
were found to be very effective against Chagas disease both in vitro and in
vivo after a short administration schedule. In this study, five compounds with specific
characteristics were selected to be administered for longer periods of time to
mice infected with the virulent Trypanosoma cruzi Y strain to further evaluate their
effectiveness as antichagasic agents and whether or not potential adverse effects occur.
Benznidazole was included for comparison purposes. Complete parasitemia depletion,
weight gain, 100% survival, and a lack of myocardial inflammation were observed
with four of the compounds and benznidazole administered intraperitoneally
at 15 or 20 mg/kg of body weight/day for 40 days. There was a significant reduction
in the number of treatment days (number of doses) necessary to induce parasitemia
suppression with all four compounds compared to that required with benznidazole.
Partial cures were obtained with only one compound tested at 15 mg/kg/day and
on the schedule mentioned above but not with benznidazole. Taken together, our
data suggest that these compounds demonstrate potent trypanocidal activity comparable
to or better than that of the reference drug, benznidazole, when they are
administered at the same dose and on the same schedule.
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Benznidazole, Chagas disease
Citação
PAPADOPOULOU, M. V. et al. Nitrotriazole-based compounds as antichagasic agents in a long-treatmenti In vivo assay. Antimicrobial Agents And Chemotherapy, v. 61, p. AAC.02717-16, 2017. Disponível em: <https://aac.asm.org/content/61/5/e02717-16>. Acesso em: 15 set. 2017.