Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential.
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2020
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Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.
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β-(1,3)-D-glucan synthase, Molecular simplification
Citação
BRETAS, A. C. O. et al. Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. Brazilian Journal of Pharmaceutical Sciences, v. 56, 2020. Disponível em: <https://www.scielo.br/j/bjps/a/9WyRKPhrqfMknLVVr9ZFnhj/>. Acesso em: 10 jun. 2021.