Acute exercise modulates the inflammatory response in adipose tissue of lean and obese mice.
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2023
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Resumo
Acute physical exercise act as a metabolic stressor, promoting activation of the immune
system, and this response could be relevant in the adipose tissue remodelling process. In
addition, some cytokines have important functions in lipolysis. Since chronic exercise
improves obesity-related metabolic and inflammatory dysfunction, herein, we investigated
the effect of acute exercise on the inflammatory responses in the adipose tissues of lean and
obese mice. Lean mice were fed a standard chow diet, whereas obese mice were fed a high-
refined carbohydrate (HC) diet for 8 weeks. Both groups were subjected to 60 min of
moderately-intensity exercise. In the epididymal adipose tissue (EAT) of lean mice, exercise
enhanced IL-6 and TNF-α levels, which correlated positively with increased serum free fatty
acid concentrations. In vivo confocal imaging of EAT vessels revealed higher recruitment of
neutrophils following exercise. Also, the number of leucocytes expressing CD11b+F480– was
elevated 6 h after exercise. Similarly, the CXCL-1 level increased at 6 h and remained high
until 24 h after exercise. Myeloperoxidase activity were increased at 6, 12, and 24 h after
exercise. Surprisingly, however, no changes were observed in EAT from obese mice
considering pro-inflammatory cytokines (IL-6 and TNF-). On the other hand, IL-13, IL-4,
and IL-10 levels were higher in obese mice after exercise. These data suggest that acute
exercise promotes an inflammatory response in the adipose tissue of lean mice that is
observed as part of its role in adipose tissue remodelling. In contrast, acute exercise promotes
an anti-inflammatory response in adipose tissue from obese mice, likely as an important tool
for restoring homeostatic.
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Cytokines, Inflammation, Obesity, High-refined carbohydrate diet
Citação
LACERDA, D. R. et al. Acute exercise modulates the inflammatory response in adipose tissue of lean and obese mice. Nutrition, v. 115, artigo 112092, nov. 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0899900723001211>. Acesso em: 01 ago. 2023.