Melancholic features related to rimonabant.

dc.contributor.authorViana, Bernardo de Mattos
dc.contributor.authorCano Prais, Hugo Alejandro
dc.contributor.authorDaker, Maurício Viotti
dc.date.accessioned2014-11-11T17:57:48Z
dc.date.available2014-11-11T17:57:48Z
dc.date.issued2009
dc.description.abstractIntroduction: Obesity is currently considered a global epidemic and its prevention and treatment is a major public health concern, demanding treatment which may combine a sociocultural approach, lifestyle modification, nutritional, pharmacological or surgical strategies. Rimonabant, an endocannabinoid antagonist, has been proposed as an agent for an average weight loss of 4 kg. However, the development of anxiety and depressive symptoms can be major side effects. Case Report: A 27-year-old businessman, after using rimonabant (20 mg/day) for 1 month for weight loss, developed a major depressive episode with melancholic features, which remitted after the interruption of rimonabant. Discussion: To our knowledge, a major depressive episode with melancholic or atypical features specifier has not been described since the initiation of rimonabant pharmacological trials. The Hospital Anxiety and Depression Scale, used in the rimonabant trials, assesses several key points of depressive patients. However, it neglects the somatic symptoms that correspond to the additional criterion for both of the mentioned features as well as suicidal ideation. The severity of an episode could also be underestimated depending on the assessment tool or on the clinical interview. Conclusion: There may be an underestimation of depressive melancholic and atypical side effects related to Rimonabant use, due to the lack of consistent assessment with the appropriate screening tools. Pharmacological strategies should be adjunctive for obesity treatment when there is a failure in the lifestyle and nutritional modification strategies. Moreover, deeper global sociocultural changes should be made in the treatment and control of the global obesity epidemic.pt_BR
dc.identifier.citationVIANA, B. M; PRAIS, H. A. C; DAKER, M. V. et al. Melancholic features related to rimonabant. General Hospital Psychiatry, v. 31, p. 583-585, 2009. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0163834309000061>. Acesso em: 03 set. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.genhosppsych.2008.12.009
dc.identifier.issn0163-8343
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3767
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico General Hospital Psychiatry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3462660863709.pt_BR
dc.subjectRimonabantpt_BR
dc.subjectDepressionpt_BR
dc.subjectMelancholic featurespt_BR
dc.subjectObesitypt_BR
dc.titleMelancholic features related to rimonabant.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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