A systematic review of drug-carrying nanosystems used in the treatment of leishmaniasis.

dc.contributor.authorRegistre, Charmante
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar
dc.contributor.authorRúbio, Karina Taciana Santos
dc.contributor.authorSantos, Orlando David Henrique dos
dc.contributor.authorCarneiro, Simone Pinto
dc.date.accessioned2023-10-17T20:02:08Z
dc.date.available2023-10-17T20:02:08Z
dc.date.issued2023pt_BR
dc.description.abstractLeishmaniasis is an infectious disease responsible for a huge rate of morbidity and mortality in humans. Chemotherapy consists of the use of pentavalent antimonial, amphotericin B, pentamidine, miltefosine, and paromomycin. However, these drugs are associated with some drawbacks such as high toxicity, administration by parenteral route, and most seriously the resistance of some strains of the parasite to them. Several strategies have been used to increase the therapeutic index and reduce the toxic effects of these drugs. Among them, the use of nanosystems that have great potential as a site-specific drug delivery system stands out. This review aims to compile results from studies that were carried out using first- and second-line antileishmanial drug- carrying nanosystems. The articles referred to here were published between 2011 and 2021. This study shows the promise of effective applicability of drug-carrying nanosystems in the field of antileishmanial therapeutics, with the perspective of providing better patient adherence to treatment, increased therapeutic efficacy, reduced toxicity of conventional drugs, as well as the potential to efficiently improve the treatment of leishmaniasis.pt_BR
dc.identifier.citationREGISTRE, C. et al. A systematic review of drug-carrying nanosystems used in the treatment of leishmaniasis. ACS Infectious Diseases, v. 9, p. 423−449, 2023. Disponível em: <https://pubs.acs.org/doi/epdf/10.1021/acsinfecdis.2c00632>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1021/acsinfecdis.2c00632pt_BR
dc.identifier.issn2373-8227
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17584
dc.identifier.uri2https://pubs.acs.org/doi/epdf/10.1021/acsinfecdis.2c00632pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectNanotechnologypt_BR
dc.subjectNanoparticlespt_BR
dc.subjectDrug deliverypt_BR
dc.subjectAntileishmanial drugspt_BR
dc.subjectAntiparasiticpt_BR
dc.titleA systematic review of drug-carrying nanosystems used in the treatment of leishmaniasis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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