Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells.
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Data
2022
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Resumo
This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different
status of TP53 (RT4, 5637 and T24). The cells were treated with
different concentrations of chrysin (20, 40, 60, 80 and 100 mM) to
analyze the cell viability, nuclear division index, mutagenicity,
apoptosis rates and expression of genes related to epigenetic
events (DNMT1, HAT1 and HDAC1). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis,
regardless TP53. Moreover, in the TP53-mutated cell lines, chrysin
modulated the expression of the DNMT1, HAT1 and HDAC1 epigenetic genes, which might be a plus to the death observed in
the cells with p53 mutation.
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Flavonoid, Bladder tumor, Cell death, Epigenetic events
Citação
LIMA, A. P. B. et al. Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells. Natural Product Research, v. 1, p. 1877-1881, set. 2022. Disponível em: <https://www.tandfonline.com/doi/epdf/10.1080/14786419.2022.2121825?needAccess=true&role=button>. Acesso em: 01 ago. 2023.