Taurine enhances voluntary alcohol intake and promotes anxiolytic-like behaviors in rats.

dc.contributor.authorPulcinelli, Rianne Remus
dc.contributor.authorPaula, Leonardo Fernandes de
dc.contributor.authorNietiedt, Natalia Azuaga
dc.contributor.authorBandiera, Solange
dc.contributor.authorHansen, Alana Witt
dc.contributor.authorIzolan, Lucas dos Reis
dc.contributor.authorAlmeida, Roberto Farina de
dc.contributor.authorGomez, Rosane
dc.date.accessioned2023-05-10T20:55:10Z
dc.date.available2023-05-10T20:55:10Z
dc.date.issued2020pt_BR
dc.description.abstractTaurine is an amino acid usually added to energy drinks. In rodents, acute taurine administration de- creases voluntary alcohol intake, and subchronic administration restores different behavioral features impaired by alcohol withdrawal. In the present study, we evaluated the effects of chronic taurine treatment on voluntary alcohol consumption and changes in behavioral parameters in rats. Adult male Wistar rats were divided into two groups and were allowed to choose from two bottles containing 20% alcohol or 0.08% saccharin (vehicle solution), or two bottles containing vehicle, 24 h per day, for 5 weeks. After 3 weeks, rats received 100 mg/kg taurine (TAU) or saline (SAL) intraperitoneally once a day for 2 weeks, and daily alcohol consumption was monitored. On days 22 and 33, rats were tested in the open- field, and on day 34, they were exposed to the light/dark task (LDT). Our results show for the first time that chronic taurine treatment enhanced voluntary alcohol intake and preference in rats, and that these changes were accompanied by an anxiolytic-like phenotype in alcohol-treated rats, possibly due to its synergistic effect with alcohol on the dopaminergic and GABAergic systems.pt_BR
dc.identifier.citationPULCINELLI, R. R. et al. Taurine enhances voluntary alcohol intake and promotes anxiolytic-like behaviors in rats. Alcohol v. 88, p. 55-63, 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0741832920302470?via%3Dihub>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.alcohol.2020.07.004pt_BR
dc.identifier.issn0741-8329
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16548
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0741832920302470?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectMesh-dividedpt_BR
dc.subjectAmino acidpt_BR
dc.subjectDrug addictionpt_BR
dc.subjectEnergy drinkspt_BR
dc.subjectEthanolpt_BR
dc.titleTaurine enhances voluntary alcohol intake and promotes anxiolytic-like behaviors in rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
ARTIGO_TaurineEnhacesVoluntary.pdf
Tamanho:
2.05 MB
Formato:
Adobe Portable Document Format
Descrição:
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: