Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production.

dc.contributor.authorGrenfell, Rafaella Fortini Queiroz
dc.contributor.authorSilva, Eduardo de Almeida Marques da
dc.contributor.authorTestasicca, Miriam Conceição de Souza
dc.contributor.authorCoelho, Eduardo Antônio Ferraz
dc.contributor.authorFernandes, Ana Paula Salles Moura
dc.contributor.authorAfonso, Luís Carlos Crocco
dc.contributor.authorRezende, Simone Aparecida
dc.date.accessioned2014-11-19T15:41:21Z
dc.date.available2014-11-19T15:41:21Z
dc.date.issued2010
dc.description.abstractThis study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishma¬nia chagasi infection. These immunogenic preparations were composed of Leishmania amazonensis or Leishmania braziliensis antigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challenged with promastigotes of L. chagasi by intravenous injection. We observed that both vaccine candidates induced a significant reduction in the parasite load of the liver, while the L. amazonensis antigenic extract also stimulated a reduction in spleen parasite load. This protection was associated with a suppression of both interleukin (IL)-10 and IL-4 cytokines by spleen cells in response to L. chagasi antigen. No change was detected in the production of IFN-γ. Our data show that these im-munogenic preparations reduce the type 2 immune response leading to the control of parasite replication.pt_BR
dc.identifier.citationGRENFELL, R. F. Q. et al. Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production. Memórias do Instituto Oswaldo Cruz, v. 105, p. 818-822, 2010. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600015&lng=en&nrm=iso&tlng=en>. Acesso em: 28 ago. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0074-02762010000600015
dc.identifier.issn0074-0276
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3967
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.pt_BR
dc.subjectVaccinept_BR
dc.subjectLeishmania chagasipt_BR
dc.subjectLeishmania braziliensispt_BR
dc.subjectLeishmania amazonensispt_BR
dc.titleAntigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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