The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months.
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2017
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Objective: Evaluate whether the polymorphism rs17782313 near MC4R gene influences long-term outcomes
after bariatric surgery.
Methods: The rs16782313 polymorphism was genotyped in 217 individuals undergoing bariatric surgery
and analyzed in detail in 141 women. Data for comorbidities, BMI, excess weight loss (EWL), and body
composition were obtained before and during 60 months after surgery.
Results: The risk allele was found in 65 (47%) of the 141 women. Pre-surgical body weight and BMI were
higher in carriers of the rs17782313 polymorphism (CC þ CT group) than in non-carriers (TT group)
(p ¼ 0.039 and 0.047, respectively). The number of women who acquired surgical success (EWL > 50%),
was lower in CC þ CT group compared to TT group (p ¼ 0.015). The minimum BMI seen during the 60
months of follow-up was higher in CC þ CT group compared to TT group (p ¼ 0.028). The number of
women who presented BMI < 30 kg/m2 (no longer classified as obesity) after 24 months of surgery was
inferior in CC þ CT group (6 out 35 patients e 17%) than in TT group (19 out 49 patients e 37%,
p ¼ 0.043). Moreover, the number of patients maintaining BMI > 35 kg/m2 were higher carriers (18 out
35 patients e 51%) compare to non-carriers (16 out 49 patients e 32%, p ¼ 0.045).
Conclusion: Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher
pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m2) and tend to maintain a
BMI > 35 kg/m2 that characterize treatment failure.
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RESENTE, C. M. M. et al. The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months. Clinical Nutrition, p. 1-17, 2017. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0261561417301796?via%3Dihub>. Acesso em: 16 jun. 2018.