Correlation of serum anti‑Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women.
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2023
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This study aimed to identify the correlation among anti-Mullerian Hormone serum levels and 25-OHD, obesity, metabolic syndrome (MetS), and sexual hormones in climacteric women classifed
according to stages of reproductive aging (SRA). A cross-sectional study was conducted with a total of
177 Brazilian climacteric women between 40 and 64 years old. Concentrations of AMH were measured
using the Access 2 Immunoassay System. A multiple linear regression analysis was used to identify
the relationship among AMH, 25-OH-D, obesity, MetS, sexual hormones, sociodemographic and
lifestyle factors. AMH levels decreased with increased age (B= − 0.059; p< 0.001), and reproductive
aging (B= − 0.483; p< 0.001). Obesity indicators, lifestyle characters, 25-OH-D levels and MetS were
not signifcantly associated with AMH serum concentration. Negative correlation was found for FSH
(B= − 0.009; p< 0.001) and LH (B= − 0.006; p= 0.004); positive correlation for E2 (B= 0.001; p= 0.011),
DHEAS (B= 0.003; p< 0.001) and SHBG (B= 0.003; p= 0.005). In the model adjusted for SRA, FSH
levels (p< 0.001) and DHEAS (p= 0.014) were associated with AMH. Although, with the adjustment
for age, only FSH remained with a signifcant association (p= 0.001). Of the other analytes, none
was associated with AMH, regardless of the model ft. Our fndings confrm that serum AMH level
decreased with age and FSH levels, but there is no correlation between AMH with obesity, 25-OH-D,
MetS or other sexual hormones in Brazilian climacteric women.
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GOUVEA, T. M.; SOUZA, L. A. C. e; LIMA, A. A. Correlation of serum anti‑Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women. Scientific Reports, v. 12, artigo 12065, 2022. Disponível em: <https://www.nature.com/articles/s41598-022-15429-7>. Acesso em: 01 ago. 2023.