Synthesis and trypanocidal activity of ent-kaurane glycosides.

dc.contributor.authorBatista, Ronan
dc.contributor.authorHumberto, Jorge Luiz
dc.contributor.authorChiari, Egler
dc.contributor.authorOliveira, Alaíde Braga de
dc.date.accessioned2015-04-14T17:57:20Z
dc.date.available2015-04-14T17:57:20Z
dc.date.issued2007
dc.description.abstractNovel ent-kaurane glucosides were synthezised by a Koenigs–Knorr reaction between C17 and C19 alcohols derived from kaurenoic acid and 2,3,4,6-tetra-O-acetyl-glucopyranosyl bromide, followed by the hydrolysis of the acetates. Main products were assayed in vitro and in vivo against blood trypomastigote forms of Trypanosoma cruzi, the aetiological agent of Chagas’ disease (American trypanosomiasis). The results allowed to establish structure–activity relationships among these derivatives, as well as pointed out the C19-methylester-C17-O-glucoside as a potential trypanocidal agent, whose trypanocidal profile was shown to be comparable to those of gentian violet and benznidazole.pt_BR
dc.identifier.citationBATISTA, R. et al. Synthesis and trypanocidal activity of ent-kaurane glycosides. Bioorganic & Medicinal Chemistry, v. 15, p. 381-391, 2007. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089606007814>. Acesso em: 02 fev. 2015.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bmc.2006.09.048
dc.identifier.issn0968-0896
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/5089
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3581340483210.pt_BR
dc.subjectKaurenoic acidpt_BR
dc.subjectKoenigs–Knorr reactionpt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.titleSynthesis and trypanocidal activity of ent-kaurane glycosides.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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