Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren : the Ouro Preto study.

dc.contributor.authorCastro, Ana Paula Pereira
dc.contributor.authorCândido, Ana Paula Carlos
dc.contributor.authorNicolato, Roney Luiz de Carvalho
dc.contributor.authorCaldas, Ivo Santana
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.date.accessioned2017-10-16T15:49:18Z
dc.date.available2017-10-16T15:49:18Z
dc.date.issued2014
dc.description.abstractPurpose Evidence suggests that plasma retinol-binding protein 4 (RBP4) and insulin resistance are related to body fat (BF). We aimed to assess the relationship between RBP4 and insulin resistance with obesity in a mixed (skin color) cohort of the Brazilian population. Methods A nested case–control study was conducted in 227 schoolchildren aged 7–14 years. Schoolchildren with a high BF percentage (% BF, C 30 for girls and C 25 for boys) were identified as the obese group (n = 137), and those with lower values were identified as the non-obese group (n = 90). Percentage of body fat (% BF) was determined by tetrapolar bioimpedance (Quantum II, RJL System), RBP4 by enzyme-linked immunosorbent assay (Immunology Consultants Laboratory), plasma fasting insulin by chemiluminescent immunoassay (Access Immunoassay System) and insulin resistance by the homeostasis model insulin resistance (IRHOMA) index. Serum lipid profile and arterial blood pressure were evaluated. Results The significant independent risk factors associated with obesity were as follows: male sex, increased serum LDL-C, RBP4 and IRHOMA. Among children with higher RBP4, the association with obesity increased significantly (from 3.1 to 8.5) in the presence of insulin resistance, when compared to higher RBP4 and non-insulin resistance. Conclusion IRHOMA and RBP4 showed significant associations with obesity and traditional CVD risk factors. They might therefore be used as a marker for CVD risk and have clinical implications in the development of comorbidities associated with obesity.pt_BR
dc.identifier.citationCASTRO, A. P. P. et al. Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study. European Journal of Nutrition, v. 53, p. 433-440, 2014. Disponível em: <http://link.springer.com/article/10.1007%2Fs00394-013-0543-5>. Acesso em: 20 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00394-013-0543-5
dc.identifier.issn1435-1293
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8940
dc.identifier.uri2http://link.springer.com/article/10.1007%2Fs00394-013-0543-5pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectBody fatpt_BR
dc.subjectInsulin resistancept_BR
dc.titleRetinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren : the Ouro Preto study.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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