Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response.
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Data
2016
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Resumo
Infection by protozoan parasites is part of the most common Tropical Neglected Diseases.
In the case of leishmaniasis, several millions of people are at risk of contracting the disease.
In spite of innumerous studies that elucidated the immune response capable of
killing the parasite, the understanding of the evasion mechanisms utilized by the parasite
to survive within the very cell responsible for its destruction is still incomplete. In this
review, we offer a new approach to the control of the immune response against the
parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine
either by directly acting on the levels of these molecules or by inducing the
expression of CD39 and CD73 on the infected cell may influence the magnitude of the
immune response against the parasite contributing to its growth and survival.
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Palavras-chave
Innate response, Immune evasion, Purinergic signaling
Citação
FIGUEIREDO, A. M.; TESTASICCA, M. C. de; AFONSO, L. C. C. Purinergic signaling and infection by Leishmania: a new approach to evasion of the immune response. Biomedical Journal, v. 39, p. 244-250, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S2319417016300385?via%3Dihub>. Acesso em: 15 set. 2017.