Neuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus.

dc.contributor.authorRocha, Alexandro Aluisio
dc.contributor.authorCota, Renata Guerra de Sá
dc.contributor.authorSilveira, Nusa de Almeida
dc.contributor.authorFranci, Janete Aparecida Anselmo
dc.contributor.authorFranci, Celso Rodrigues
dc.date.accessioned2015-04-01T17:35:36Z
dc.date.available2015-04-01T17:35:36Z
dc.date.issued2006
dc.description.abstractThe multiple control of gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) secretion involves locus coeruleus (LC) and neuropeptide Y (NPY). The objective of the present study was to analyze the possible contribution of the LC to the control of NPY activity in the medial basal hypothalamus (MBH) and medial preoptic area (MPOA) during the LH surge induced by estrogen (E2) and progesterone (P4). Ovariectomized adult Wistar rats were submitted to the hormone replacement and to the LC bilateral lesion (lesioned groups) or sham surgery (control groups). On the day of the experiment the rats were decapitated at 11:00, 13:00, 15:00 and 17:00 h for plasma and brain collection. Plasma LH was determined by radioimmunoassay. MBH and MPOA were microdissected for the measurement of NPY by enzyme immunoassay. NPY mRNA levels in MBH were assessed by the ribonuclease protection assay. The results showed that LC lesion: decreased the plasma LH; increased the content of NPY in the MBH and reduced the increase of NPY content in the MPOA during afternoon in which LH surge was induced. The increased NPY content in MBH was not associated with an increase of the respective mRNA content, suggesting the action of postranscriptional and/or posttranslational mechanisms. In conclusion, the NPY activity in the MPOA on LH surge induced by estrogen and progesterone could be controlled by LC through two ways, at least: one direct way, by the release of NPY from LC neurons terminals that innervate the MPOA and they release NA and NPY; one indirect way, by the control of release but not synthesis of NPY from neurons in the MBH which innervate the MPOA.pt_BR
dc.identifier.citationROCHA, A. A. et al. Neuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus. Neuropeptides, Edinburgh, v. 40, p. 57-63, 2006. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0143417905001137>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.npep.2005.10.005
dc.identifier.issn0143-4179
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4927
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Neuropeptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120362267.pt_BR
dc.subjectLocus coeruleuspt_BR
dc.subjectNeuropeptidept_BR
dc.subjectNeuropeptidept_BR
dc.subjectLuteinizing hormonept_BR
dc.subjectMedial preoptic areapt_BR
dc.titleNeuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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