Severe pediatric asthma refractory to treatment : the ongoing challenge of exacerbation.
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Data
2017
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The objective of this study was to review the last 16 years of literature on the clinical and functional risk factors for asthma exacerbation, as well as
on biochemical parameters in severe pediatric asthma refractory to treatment (SPART). In searches of the Cochrane/Brazilian Virtual Library of Health,
Latin American and Caribbean Health Sciences Literature, Medline, Brazilian Office for the Advancement of Higher Education, and PubMed databases, we
employed the following search terms/strings: “severe asthma” or “refractory asthma” or “problematic asthma” or “difficult-to-treat asthma”; “exacerbation”;
“risk factors” or “predictors”; and “pediatric” or “children and adolescents”. We limited our searches to articles published between 1999 and 2016. We
selected 26 original or review articles on severe pediatric asthma that addressed age, recent severe exacerbations, the level of asthma control, regular followup,
comorbidities, behavioral factors, viral infection, and passive smoking, biomarkers of inflammation, serum vitamin D levels, and pulmonary function. However,
we found very few studies dealing with SPART. Severe asthma is a heterogeneous, dynamic disease in which the various predictors of exacerbation described
assess different aspects of the disease and are complementary. Such factors should be analyzed from a multifactorial and individualized perspective, because
many of them are potentially modifiable.
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Palavras-chave
Severe refractory asthma, Exacerbation, Predictive factors, Children and adolescents
Citação
QUEIROZ, M. V. N. P. de; QUEIROZ, J. V. C. de; LASMAR, L. M. de L. B. F. Severe pediatric asthma refractory to treatment : the ongoing challenge of exacerbation. Clinical Research in Pulmonology, v. 5, p. 1043-1050, 2017. Disponível em: <https://www.jscimedcentral.com/Pulmonology/pulmonology-5-1043.pdf>. Acesso em: 05 abr. 2018.