Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens.

dc.contributor.authorNizer, Waleska Stephanie da Cruz
dc.contributor.authorFerraz, Ariane Coelho
dc.contributor.authorMoraes, Thaís de Fátima Silva
dc.contributor.authorLima, William Gustavo de
dc.contributor.authorSantos, Josana Pereira dos
dc.contributor.authorDuarte, Lucienir Pains
dc.contributor.authorMagalhães, Cíntia Lopes de Brito
dc.contributor.authorVieira Filho, Sidney Augusto
dc.contributor.authorMagalhães, José Carlos de
dc.date.accessioned2023-12-18T19:36:03Z
dc.date.available2023-12-18T19:36:03Z
dc.date.issued2022pt_BR
dc.description.abstractThe expression of virulence factors, such as biofilm formation, in association with the acquisition of resistance to multiple drugs, has evidenced the need for new and effective antimicrobial agents against Staphylococcus aureus. The evaluation of the pharmacological properties of plant-derived compounds is a promising alternative to the development of new antimicrobials. In this study, we aimed to evaluate the antibacterial, antibiofilm, and the synergistic and cytotoxic effects of netzahualcoyonol isolated from Salacia multiflora (Lam.) DC. roots. Netzahualcoyonol presented bacteriostatic (1.56–25.0 mg/mL) and bactericidal (25.0–400.0 mg/mL) effects against Gram-positive bacteria, disrupted the biofilm of S. aureus, and presented a synergistic effect after its combination with b-lactams and aminoglycosides. The low cytotoxicity of netzahualcoyonol (Selectivity Index (SI) for S. aureus (2.56), S. saprophyticus (20.56), and Bacillus subtilis (1.28)) suggests a good security profile. Taken together, these results show that netzahualcoyonol is promising for the development of a new effective antibacterial agent.pt_BR
dc.identifier.citationNIZER, W. S. da C. et al. Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens. Natural Product Research, v. 36, n. 22, p. 5904-5909, nov. 2022. Disponível em: <https://www.sciencedirect.com/org/science/article/pii/S1478641922052810>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14786419.2021.2023865pt_BR
dc.identifier.issn1478-6427
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17949
dc.identifier.uri2https://www.sciencedirect.com/org/science/article/pii/S1478641922052810pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectNetzahualcoyonolpt_BR
dc.subjectCelastraceaept_BR
dc.subjectAntibiofilmpt_BR
dc.subjectAntibacterialpt_BR
dc.subjectGram-positivept_BR
dc.titleNetzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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