Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game.
dc.contributor.author | Coelho, Daniel Barbosa | |
dc.contributor.author | Pimenta, Eduardo Mendonça | |
dc.contributor.author | Cruz, Izinara Rosse da | |
dc.contributor.author | Veneroso, Christiano Eduardo | |
dc.contributor.author | Pussieldi, Guilherme de Azambuja | |
dc.contributor.author | Oliveira, Lenice Kappes Becker | |
dc.contributor.author | Oliveira, Emerson Cruz de | |
dc.contributor.author | Carvalho, Maria Raquel Santos | |
dc.contributor.author | Garcia, Emerson Silami | |
dc.date.accessioned | 2019-04-25T14:03:43Z | |
dc.date.available | 2019-04-25T14:03:43Z | |
dc.date.issued | 2018 | |
dc.description.abstract | The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/ RX (p , 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/ RX group (p , 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p , 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athletes | pt_BR |
dc.identifier.citation | COELHO, D. B. et al. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. Journal of Strength and Conditioning Research, v. Published Ahead-of-Print, p. 3-10, maio 2018. Disponível em: <https://journals.lww.com/nsca-jscr/Abstract/publishahead/Alpha_Actinin_3_R577X_Polymorphism_Influences.95358.aspx>. Acesso em: 20 fev. 2019. | pt_BR |
dc.identifier.issn | 1064-8011 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11129 | |
dc.identifier.uri2 | https://journals.lww.com/nsca-jscr/Abstract/publishahead/Alpha_Actinin_3_R577X_Polymorphism_Influences.95358.aspx#print-article-link | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | ACTN3 | pt_BR |
dc.subject | Physiological stress | pt_BR |
dc.subject | Performance | pt_BR |
dc.subject | Muscle microtrauma | pt_BR |
dc.subject | Blood markers | pt_BR |
dc.title | Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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