Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game.
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Data
2018
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Resumo
The purpose of this
study was to evaluate indicators of muscle damage and hormonal
responses after soccer matches and its relation to alpha-actinin-3
(ACTN3) gene expression (XX vs. RR/RX), considering that the R
allele produces alpha-actinin-3 and provides greater muscle
strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples
were collected immediately before, after, 2, and 4 hours after the
games to assess muscle damage (creatine kinase [CK] and
alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol,
and testosterone). Postgame CK was higher as compared to the
pregame values in both groups and it was also higher in the RR/
RX (p , 0.05) than in the XX. The concentrations of alpha-actin
and IL-6 were similar for both groups and did not change over
time. Testosterone was increased after the game only in the RR/
RX group (p , 0.05). Cortisol concentrations in group RR/RX
were higher immediately after the game than before the game, and
2 and 4 hours after the game the concentration decreased
(p , 0.05). The RR and RX individuals presented higher markers
of muscle microtrauma and hormonal stress, probably because
they performed more speed and power actions during the game,
which is a self-regulated activity. From the different responses
presented by RR/RX and XX genotypes, we conclude that the
genotypic profile should be taken into account when planning
training workloads and recovery of athletes
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Palavras-chave
ACTN3, Physiological stress, Performance, Muscle microtrauma, Blood markers
Citação
COELHO, D. B. et al. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. Journal of Strength and Conditioning Research, v. Published Ahead-of-Print, p. 3-10, maio 2018. Disponível em: <https://journals.lww.com/nsca-jscr/Abstract/publishahead/Alpha_Actinin_3_R577X_Polymorphism_Influences.95358.aspx>. Acesso em: 20 fev. 2019.