The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats.
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2017
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Twenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the
ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10%
(FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was
performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal
tubules. We evaluated the redox imbalance through the catalase and superoxide dismutase activity as
well as oxidative damage by lipid peroxidation. Inflammatory chemokines CCL2, CCL3 and CCL5 were
analyzed by enzyme immunoassays. There was an increase in the concentration of urea in FA10%
compared with CG and FA1%. The levels of creatinine, renal lumen and lipid peroxidation increased in all
FA-treated groups compared with CG. The concentration of uric acid in FA10% was lower compared with
all other groups. There was an increase in the space of Bowman's capsule in FA5% and FA10% compared
with CG and FA1%. However, the superoxide dismutase activity was higher in FA5% compared with other
groups while CCL5 was higher in FA1% compared with CG. The exposure to formaldehyde in a short
period of time leads to changes in the kidney function, inflammation and morphology, as well as
promoted the increase of superoxide dismutase activity and oxidative damage.
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Renal tissue
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RAMOS, C. O. et al. The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats. Experimental And Toxicologic Pathology, v. 69, p. 367-372, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0940299316302962?via%3Dihub>. Acesso em: 15 set. 2017.