Thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress.

dc.contributor.authorSantos, Áquila Rodrigues Costa
dc.contributor.authorAbreu, Aline Rezende Ribeiro de
dc.contributor.authorNoronha, Sylvana Izaura Salyba Rendeiro de
dc.contributor.authorReis, Thayane Oliveira
dc.contributor.authorSantos, Daisy Motta
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.contributor.authorSilva Junior, Luiz Gonzaga da
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.contributor.authorRodrigues, Cibele Velloso
dc.date.accessioned2023-12-18T18:10:06Z
dc.date.available2023-12-18T18:10:06Z
dc.date.issued2023pt_BR
dc.description.abstractObesity and stress are related to cardiovascular diseases. Rats fed a high-fat diet (HFD) show increased cardiovascular reactivity to emotional stress and altered defensive behavioral responses. Indeed, changes in thermoregulatory responses in an aversive environment are observed in these animals. However, studies aimed at clarifying the physiological mechanisms linking obesity, stress hyperreactivity and behavioral changes are needed. The aim of this study was to evaluate the changes in thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress. Nine-week high-fat diet protocol was effective in inducing obesity by increasing weight gain, fat mass, adiposity index, white epididymal, retroperitoneal, inguinal and brown adipose tissue. Animals induced to obesity and subjected to stress (HFDS group) by the intruder animal method showed increases in heart rate (HR), core body temperature and tail temperature. HFDS showed an increase in the first exposure to the closed arm (anxiety-like behavior) in elevated T-Maze (ETM). The groups did not differ with respect to panic behavior assessed in the ETM and locomotor activity in the open field test. Our study shows that HFDS animals presented increased reactivity to stress with higher stress hyperthermia and anxious behavior. Thus, our results present relevant information regarding stress responsiveness and behavioral changes in obese animals.pt_BR
dc.identifier.citationSANTOS, A. R. C. et al. Thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress. Physiology & Behavior, v. 266, artigo 114181, jul. 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0031938423001099>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.physbeh.2023.114181pt_BR
dc.identifier.issn0031-9384
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17944
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0031938423001099pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectObesitypt_BR
dc.subjectStresspt_BR
dc.subjectThermoregulatory responsespt_BR
dc.subjectHeart ratept_BR
dc.subjectAnxiety-like behaviorpt_BR
dc.titleThermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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