Immune system challenge improves recognition memory and reverses malaria‐induced cognitive impairment in mice.
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2021
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The immune system plays a role in the maintenance of healthy neurocognitive function. Diferent
patterns of immune response triggered by distinct stimuli may afect nervous functions through
regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here,
we investigate the efect of immune stimulation on cognitive-behavioural parameters in healthy mice
and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that
immune modulation induced by a specifc combination of immune stimuli that induce a type 2 immune
response can enhance long-term recognition memory in healthy adult mice subjected to novel object
recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour
in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our
fndings suggest a potential use of immunogens for boosting and recovering recognition memory that
may be impaired by chronic and infectious diseases and by the efects of ageing.
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SOUZA, L. P. de et al. Immune system challenge improves recognition memory and reverses malaria‐induced cognitive impairment in mice. Scientific Reports, v. 11, artigo 14857, 2021. Disponível em: <https://www.nature.com/articles/s41598-021-94167-8>. Acesso em: 11 out. 2022.