Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children.
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2018
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Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the
presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect
glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This
study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk,
and insulin resistance with concentrations of resistin and visfatin, in children.
Methods: A cross-sectional study was developed with 178 children of 6–10 years old enrolled in public city
schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard
procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and
visfatin with variables of interest.
Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and
waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between
conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps
skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto-
height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was
negatively associated with the HOMA-IR index.
Conclusions: Our study shows an association between anthropometric and biochemical variables related to
visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In
addition, both adipokines are strongly related to central obesity, in children.
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Adipokines, Adipose tissue, Insulin resistance, Waist-height ratio, Adiposity
Citação
SIMÕES, N. F. et al. Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children. Nutrire - Revista da Sociedade Brasileira de Alimentação e Nutrição, v. 43, p. 1, 2018. Disponível em: <https://nutrirejournal.biomedcentral.com/articles/10.1186/s41110-018-0060-7>. Acesso em: 16 jun. 2018.