Theracurmin modulates cardiac inflammation in experimental model of Trypanosoma cruzi infection.
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2023
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Theracurmin is a nanoparticle formulation derived from curcumin, a bioactive compound
known for its antioxidant and anti-inflammatory properties. Trypanosoma cruzi, the etiological agent
of Chagas disease, triggers an intense inflammatory response in mammals and also causes severe
tissue damage. To evaluate the immunomodulatory and antiparasitic effects of Theracurmin, Swiss
mice were experimentally infected with 103
trypomastigote forms of the Colombian strain of T. cruzi
and submitted to daily therapy with 30 mg/kg of Theracurmin. In addition, daily benznidazole
therapy (100 mg/kg) was performed as a positive control. We evaluated the systemic and tissue
parasitism, the survival and the body mass rate, the release of inflammatory mediators (TNF, IL-6,
IL-15, CCL2 and creatine kinase) and the tissue inflammation at day 30 post-infection. Theracurmin
therapy reduced the parasitemia curve without altering the animals’ survival rate, and it protected
mice from losing body mass. Theracurmin also reduced CCL2 in cardiac tissue, IL-15 in cardiac
and skeletal tissue, and plasma CK. Even without effects on TNF and IL-6 production and tissue
amastigote nests, Theracurmin reduced the leukocyte infiltrate in both evaluated tissues, even in the
case of more effective results observed to the benznidazole treatment. Our data suggest Theracurmin
has an immunomodulatory (CCL2, IL-15, CK and tissue leukocyte infiltration) and a trypanocidal
effect (on circulating parasites) during experimental infection triggered by the Colombian strain of
T. cruzi. Further investigations are necessary to comprehend the Theracurmin role performed in
combination with benznidazole or other potential anti-T. cruzi chemical compounds.
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Cardiac tissue
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SILVA, V. L. T. e et al. Theracurmin modulates cardiac inflammation in experimental model of Trypanosoma cruzi infection. Tropical Medicine and Infectious Disease, v. 8, n. 7, artigo 343, 2023. Disponível em: <https://www.mdpi.com/2414-6366/8/7/343>. Acesso em: 01 ago. 2023.