Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression.
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2020
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Longitudinal and some experimental studies have showed the potential of caffeine to counteract some depressive
behaviors and synaptic dysfunctions. In this study, we investigated the potential of caffeine in preventing be-
havioral outcomes, neurodegeneration and synaptic proteins alterations in a mice model of agitated depression
by bilateral olfactory bulbectomy (OB). For this purpose, bulbectomized mice received caffeine (0.3 g/L and
1.0 g/L, drinking water), during the active cycle, for seven weeks (two before the surgery and throughout five
weeks after OB). Caffeine prevented OBinduced hyperactivity and recognition memory impairment and rescue
self care and motivational behavior. In the frontal cortex, bulbectomized mice presented increase in the ade-
nosine A1 receptors (A1R) and GFAP, while adenosine A2A receptors (A2AR) increased in the hippocampus and
striatum and SNAP-25 was decreased in frontal cortex and striatum. Caffeine increased A1R in the striatum of
bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25
in the frontal cortex. Astrogliosis observed in the polymorphic layer of the dentate gyrus of OB mice was pre-
vented by caffeine as well as the neurodegeneration in the striatum and piriform cortex. Based on these beha-
vioral and neurochemical evidences, caffeine confirms its efficacy in preventing neurodegeneration associated
with memory impairment and may be considered as a promising therapeutic tool in the prophylaxis and/or
treatment of depression.
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Neurodegeneration, Adenosine receptors, Olfactory bulbectomy, Caffeine, Memory
Citação
MACHADO, D. G. et al. Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 98, artigo 109776, mar. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0278584619304828?via%3Dihub>. Acesso em: 11 out. 2022.