Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.
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2022
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Resumo
Data recently reported by our group indicate that stimulation with a pool of
immunogens capable of eliciting type 2 immune responses can restore the
cognitive and behavioral dysfunctions recorded after a single episode of nonsevere rodent malaria caused by Plasmodium berghei ANKA. Here we explored
the hypothesis that isolated immunization with one of the type 2 immune
response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine,
may revert damages associated with malaria. To investigate this possibility, we
studied the dynamics of cognitive deficits and anxiety-like phenotype following
non-severe experimental malaria and evaluated the effects of immunization
with both dT and of a pool of type 2 immune stimuli in reversing these
impairments. Locomotor activity and long-term memory deficits were
assessed through the open field test (OFT) and novel object recognition task
(NORT), while the anxiety-like phenotype was assessed by OFT and light/dark
task (LDT). Our results indicate that poor performance in cognitive-behavioral
tests can be detected as early as the 12th day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection.
The single immunization strategy with the human dT vaccine showed promise
in reversal of long-term memory deficits in NORT, and anxiety-like behavior in
OFT and LDT.
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Behavior, Cognitive dysfunction, Diphtheria-tetanus vaccine, Immunomodulation, Non-severe experimental malaria
Citação
GONÇALVES, P. R. et al. Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria. Frontiers in Immunology, v. 13, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021211/full>. Acesso em: 01 ago. 2023.