Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/979
Title: Trypanosoma cruzi : immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes.
Authors: Vital, Wendel Coura
Carneiro, Cláudia Martins
Martins, Helen Rodrigues
Lana, Marta de
Veloso, Vanja Maria
Carvalho, Andréa Teixeira de
Bahia, Maria Terezinha
Oliveira, Rodrigo Corrêa de
Martins Filho, Olindo Assis
Tafuri, Wagner Luiz
Reis, Alexandre Barbosa
Keywords: Trypanosoma cruzi
Chagas' disease
Canine model
Class and subclass of immunoglobulins
Issue Date: 2008
Citation: VITAL, W. C. et al. Trypanosoma cruzi : immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes. Experimental Parasitology, v. 120, n. 3, p. 269-274, nov. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489408001963>. Acesso em: 05 jul. 2012
Abstract: A detailed investigation has been carried out about the serological profiles of groups of dogs experimen-tally infected with metacyclic (MT) or blood (BT) trypomastigotes of Berenice-78 Trypanosoma cruzi strain. Peripheral blood was collected from infected dogs and uninfected controls, weekly during 35 days following the acute phase of infection, and immunoglobulin profiles were determined by ELISA. Dogs infected with BT exhibited unaltered levels of IgG2, increases in IgM, IgE, IgA, IgG and IgG1. In contrast, dogs infected with MT presented unaltered levels of IgE and IgG1 and an increase in IgM, IgA, IgG and IgG2 levels. Compared with the MT group, animals infected with BT showed significant increases in IgM on days 7, 14 and 28, in IgA on days 7, 14 and 21, in IgE on days 7 and 14, in IgG on days 14 and 28, and in IgG1 on days 7, 14 and 21. Parasitemia levels of the infected animals were measured over the same time period. No correlations were found between the immunoglobulin profiles and the parasi-temia levels. The results demonstrated that the inoculum source (BT or MT) influence the immunoglob-ulin isotype profile that may drive distinct outcome of acute canine Chagas disease
URI: http://www.repositorio.ufop.br/handle/123456789/979
ISSN: 00144894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990771185.
Appears in Collections:DEACL - Artigos publicados em periódicos

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