Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/972
Title: Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis.
Authors: Giunchetti, Rodolfo Cordeiro
Mayrink, Wilson
Carneiro, Cláudia Martins
Oliveira, Rodrigo Corrêa de
Martins Filho, Olindo Assis
Marques, Marcos José
Tafuri, Wagner Luiz
Reis, Alexandre Barbosa
Keywords: Dog
Histopathology
Immunohistochemistry
Leishmania chagasi
Liver
Issue Date: 2008
Citation: GIUNCHETTI, R. C. et al. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. Veterinary Science, v. 84, n. 2, p. 269-277, abr. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528807001245>. Acesso em: 05 jul. 2012.
Abstract: The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in anine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi[i.e., asymptomatic (AD, n = 12), oligosymptomatic (OD,n = 12) and symptomatic (SD,n = 17)] were assessed and compared with a group of non-infected dogs (NID,n = 11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasit-ism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to pro-gression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.
URI: http://www.repositorio.ufop.br/handle/123456789/972
ISSN: 03784312
metadata.dc.rights.license: O periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420662301.
Appears in Collections:DEACL - Artigos publicados em periódicos

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