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Title: Cardiovascular responses to L-glutamate microinjection into the NTS are abrogated by reduced glutathione.
Authors: Granato, Álisson Silva
Gomes, Paula Magalhães
Sá, Renato Willian Martins
Borges, Gabriel Silva Marques
Alzamora, Andréia Carvalho
Oliveira, Lisandra Brandino de
Toney, Glenn M.
Cardoso, Leonardo Máximo
Keywords: Blood pressure
Nucleus tractus solitaries
Issue Date: 2017
Citation: GRANATO, A. S. et al. Cardiovascular responses to L-glutamate microinjection into the NTS are abrogated by reduced glutathione. Neuroscience Letters, v. 642, p. 142-147, 2017. Disponível em: <>. Acesso em: 15 set. 2017.
Abstract: Redox imbalance in regions of the CNS controlling blood pressure is increasingly recognized as a leading factor for hypertension. Nucleus tractus solitarius (NTS) of the dorsomedial medulla is the main region receiving excitatory visceral sensory inputs that modulate autonomic efferent drive to the cardiovascular system. This study sought to determine the capacity of reduced glutathione, a major bioactive antioxidant, to modulate NTS-mediated control of cardiovascular function in unanaesthetized rats. Male Fischer 344 rats were used for microinjection experiments. Cardiovascular responses to l-glutamate were first used to verify accurate placement of injections into the dorsomedial region comprising the NTS. Next, responses to GSH or vehicle were recorded followed by responses to l-glutamate again at the same site. GSH microinjection increased mean arterial pressure (MAP) compared to vehicle and abrogated responses to subsequent injection of l-glutamate. These data indicate that GSH microinjection into the NTS affects blood pressure regulation by dorsomedial neuronal circuits and blunts l-glutamate driven excitation in this region. These findings raise the possibility that increased antioxidant actions of GSH in NTS could contribute to autonomic control dysfunctions of the cardiovascular system.
ISSN: 03043940
metadata.dc.rights.license: O periódico Neuroscience Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210820629012.
Appears in Collections:DECBI - Artigos publicados em periódicos

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