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Title: MTHFR and MTR polymorphisms and breast cancer in Brazilian women.
Authors: Conceição, Lisiane Lopes da
Pessoa, Milene Cristine
Hermsdorff, Helen Hermana Miranda
Freitas, Renata Nascimento de
Peluzio, Maria do Carmo Gouveia
Keywords: One-carbon metabolism
Issue Date: 2016
Citation: CONCEIÇÃO, L. L. C. et al. MTHFR and MTR polymorphisms and breast cancer in Brazilian women. World Journal of Research and Review, v. 2, n. 6, p. 29-32, jun. 2016. Disponível em: <>. Acesso em: 29 ago. 2017.
Abstract: Breast cancer (BC) is the second most common cancer, and mortality rates remain high among Brazilian women. However, the role of single nucleotide polymorphisms (SNPs) in one-carbon metabolism genes in breast cancer in Brazilian women is less clear. We aimed examine the association between the SNPs, in two genes in one-carbon metabolism alone and in cumulation, and the risk of breast cancer in an Brazilian population based case-control study of 257 breast cancer cases and 177 controls. Our hypothesis was woman who carries more risk genotypes has a higher susceptibility for developing breast cancer. Genotyping for MTHFR C677T and MTR A2756G polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) method. Our results in population studied indicated that 677 C>T and 2756 A>G substitution does not appear to influence the risk of breast cancer. The cumulative effect was not observed with the OR being gradually elevated with increasing number of risk genotypes. However, larger studies are needed to further examine this interactions in this pathway and breast cancer risk in Brazilian women, as well in women of others nationalities.
ISSN: 2455-3956
Appears in Collections:DENCS - Artigos publicados em periódicos

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