Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/8525
Título: | Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN. |
Autor(es): | Oliveira, Riva de Paula Abate, Jess Porter Dilks, Kieran Landis, Jessica Ashraf, Jasmine Murphy, Coleen T. Blackwell, T. Keith |
Palavras-chave: | Aging Caenorhabditis elegans Insulin signaling Detoxification |
Data do documento: | 2009 |
Referência: | OLIVEIRA, R. de P. et al. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN. Aging Cell, v. 8, p. 524-541, 2009. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00501.x/abstract>. Acesso em: 20 de jul. 2017. |
Resumo: | Studies in model organisms have identified regulatory processes that profoundly influence aging, many of which modulate resistance against environmental or metabolic stresses. In Caenorhabditis elegans, the transcription regulator SKN-1 is important for oxidative stress resistance and acts in multiple longevity pathways. SKN-1 is the ortholog of mammalian Nrf proteins, which induce Phase 2 detoxification genes in response to stress. Phase 2 enzymes defend against oxygen radicals and conjugate electrophiles that are produced by Phase 1 detoxification enzymes, which metabolize lipophilic compounds. Here, we have used expression profiling to identify genes and processes that are regulated by SKN-1 under normal and stress–response conditions. Under nonstressed conditions SKN-1 upregulates numerous genes involved in detoxification, cellular repair, and other functions, and downregulates a set of genes that reduce stress resistance and lifespan. Many of these genes appear to be direct SKN-1 targets, based upon presence of predicted SKN-binding sites in their promoters. The metalloid sodium arsenite induces skn-1-dependent activation of certain detoxification gene groups, including some that were not SKN-1- upregulated under normal conditions. An organic peroxide also triggers induction of a discrete Phase 2 gene set, but additionally stimulates a broad SKN-1-independent response. We conclude that under normal conditions SKN-1 has a wide range of functions in detoxification and other processes, including modulating mechanisms that reduce lifespan. In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8525 |
Link para o artigo: | http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00501.x/abstract |
DOI: | https://doi.org/10.1111/j.1474-9726.2009.00501.x |
ISSN: | 1474-9726 |
Aparece nas coleções: | DEBIO - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_ConditionAdaptedStress.pdf Restricted Access | 1 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.