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Title: A potential link among antioxidant enzymes, histopathology, and trace elements in canine visceral leishmaniasis.
Authors: Souza, Carolina Carvalho de
Barreto, Tatiane Oliveira
Silva, Sydnei Magno da
Pinto, Aldair Junio Woyames
Figueiredo, Maria Marta
Rocha, Olguita Geralda Ferreira
Cangussú, Silvia Dantas
Tafuri, Wagner Luiz
Keywords: Iron
Issue Date: 2014
Citation: SOUZA, C. C. de et al. A potential link among antioxidant enzymes, histopathology, and trace elements in canine visceral leishmaniasis. International Journal of Experimental Pathology, v. 95, p. 260-270, 2014. Disponível em: <>. Acesso em: 20 mar. 2017.
Abstract: Canine visceral leishmaniasis (CVL) is a severe and fatal systemic chronic inflammatory disease. We investigated the alterations in, and potential associations among, antioxidant enzymes, trace elements and histopathology in CVL. Blood and tissue levels of Cu-Zn superoxide dismutase, catalase and glutathione peroxidase were measured in mixed-breed dogs naturally infected with Leishmania infantum chagasi, symptomatic (n = 19) and asymptomatic (n = 11). Serum levels of copper, iron, zinc, selenium and nitric oxide, and plasma lipid peroxidation were measured. Histological and morphometric analyses were conducted of lesions in liver, spleen and lymph nodes. We found lower blood catalase and glutathione peroxidase activity to be correlated with lower iron and selenium respectively. However, higher activity of Cu- Zn superoxide dismutase was not correlated with the increase in copper and decreased in zinc observed in infected animals compared to controls. Organ tissue was characterized by lower enzyme activity in infected dogs than in controls, but this was not correlated with trace elements. Lipid peroxidation was higher in symptomatic than in asymptomatic and control dogs and was associated with lesions such as chronic inflammatory reaction, congestion, haemosiderin and fibrosis. Systemic iron deposition was observed primarily in the symptomatic dogs showing a higher tissue parasite load. Dogs with symptomatic CVL displayed enhanced LPO and Fe tissue deposition associated with decreased levels of antioxidant enzymes. These results showed new points in the pathology of CVL and might open new treatment perspectives associated with antioxidants and the role of iron in the pathogenesis of CVL.
ISSN: 1365-2613
metadata.dc.rights.license: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Fonte: o próprio artigo.
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