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|Title:||Synthesis of indolines via a SmI promoted domino nitro reduction-intramolecular aza-Michael reaction.|
|Authors:||Ramos, Josierika Alexandra Ferreira|
Araújo, Carolina S.
Nagem, Tanus Jorge
Taylor, Jason Guy
|Citation:||RAMOS, J. A. F et al. Synthesis of indolines via a SmI promoted domino nitro reduction-intramolecular aza-Michael reaction. Journal of Heterocyclic Chemistry, v. 52, p. 54-58, 2015. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jhet.1982/abstract>. Acesso em: 20 abr. 2017.|
|Abstract:||A simple and straightforward synthesis of substituted indolines based on a domino nitro reduction intramolec-ular aza-Michael reaction is described. The reaction employs Samarium diiodide under mild conditions for theaddition of dibromoacetic acid to substituted 2-(2-nitrophenyl) acetaldehyde derivatives and their subsequent cycli-zation upon nitro group reduction to provide corresponding indoline heterocycles in good yields. This “one pot”strategy also permitted the expeditious synthesis of a 1,2,3,4-tetrahydroquinoline, whereas the seven-membered2,3,4,5-tetrahydrobenzoazepines compounds were not formed under these reaction conditions.|
|Appears in Collections:||DEQUI - Artigos publicados em periódicos|
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