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Title: Antiproliferative effect of benzophenones and their infl uence on cathepsin activity.
Authors: Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, Marcelo Henrique dos
Kohn, Luciana K.
Martins, Felipe Terra
Nagem, Tanus Jorge
Alencar, Severino Matias de
Carvalho, João Ernesto de
Rosalen, Pedro Luiz
Keywords: Antiproliferative
Rheedia brasiliensis
Issue Date: 2010
Citation: MURATA, R. M. et al. Antiproliferative effect of benzophenones and their infl uence on cathepsin activity. Phytotherapy Research , v. 24, p. 379-383, 2010. Disponível em: <>. Acesso em: 20 mai. 2017.
Abstract: The antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated garciniaphenone and the tetraprenylated benzophenone 7-epiclusianone, was investigated against human cancer cell lines. The antiproliferative activity on melanoma (UACC-62), breast (MCF-7), drug-resistant breast (NCI-ADR), lung/non-small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786-0), lung (NCI-460) and tongue (CRL-1624 and CRL-1623) cancer cells was determined using spectrophotometric quantifi cation of the cellular protein content. The effect of these benzophenones on the activity of cathepsins B and G was also investigated. Garciniaphenone displayed cytostatic activity in all cell lines, whereas 7- epiclusianone showed a dose-dependent cytotoxic effect. The IC50 values for cell proliferation revealed that 7-epiclusianone is more active than garciniaphenone against most of the cell lines. Furthermore, the antiproliferative effects demonstrated by garciniaphenone and 7-epiclusianone were related to their cathepsin inhibiting properties. In conclusion, 7-epiclusianone is a promising naturally occurring agent which displays multiple inhibitory effects which may be working in concert to inhibit cancer cell proliferation in vitro. The putative pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition.
ISSN: 1099-1573
Appears in Collections:DEQUI - Artigos publicados em periódicos

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