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Title: Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.
Authors: Corrêa, Paulo Roberto Ceridóreo
Miranda, Roqueline Rodrigues Silva de
Duarte, Lucienir Pains
Silva, Grácia Divina de Fátima
Vieira Filho, Sidney Augusto
Okuma, Adriana Akemi
Carazza, Fernando
Díaz, José Andrés Morgado
Pinge Filho, Phileno
Yamauchi, Lucy Megumi
Nakamura, Celso Vataru
Ogatta, Sueli Fumie Yamada
Issue Date: 2012
Citation: CORRÊA, P. R. C. et al. Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. Pathogens and Global Health, v. 106, p. 107, 2012. Disponível em: <>. Acesso em: 20 jan. 2017.
Abstract: We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.
ISSN: 2047-7732
Appears in Collections:DEFAR - Artigos publicados em periódicos

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