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Título: | Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. |
Autor(es): | Corrêa, Paulo Roberto Ceridóreo Miranda, Roqueline Rodrigues Silva de Duarte, Lucienir Pains Silva, Grácia Divina de Fátima Vieira Filho, Sidney Augusto Okuma, Adriana Akemi Carazza, Fernando Díaz, José Andrés Morgado Pinge Filho, Phileno Yamauchi, Lucy Megumi Nakamura, Celso Vataru Ogatta, Sueli Fumie Yamada |
Data do documento: | 2012 |
Referência: | CORRÊA, P. R. C. et al. Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. Pathogens and Global Health, v. 106, p. 107, 2012. Disponível em: <http://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002>. Acesso em: 20 jan. 2017. |
Resumo: | We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7506 |
Link para o artigo: | http://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002 |
DOI: | https://doi.org/10.1179/2047773212Y.0000000002 |
ISSN: | 2047-7732 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_AntimicrobialActivitySynthetic.pdf Restricted Access | 458,99 kB | Adobe PDF | Visualizar/Abrir |
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