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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Correa, Rodrigo de Souza | - |
dc.contributor.author | Silva, Monize Martins da | - |
dc.contributor.author | Graminha, Angelica Ellen | - |
dc.contributor.author | Meira, Cássio Santana | - |
dc.contributor.author | Santos, Jamyle Andrade Ferreira dos | - |
dc.contributor.author | Moreira, Diogo Rodrigo de Magalhães | - |
dc.contributor.author | Soares, Milena Botelho Pereira | - |
dc.contributor.author | Poelhsitz, Gustavo Von | - |
dc.contributor.author | Castellano, Eduardo Ernesto | - |
dc.contributor.author | Bloch Junior, Carlos | - |
dc.contributor.author | Cominetti, Márcia Regina | - |
dc.contributor.author | Batista, Alzir Azevedo | - |
dc.date.accessioned | 2016-11-07T13:17:56Z | - |
dc.date.available | 2016-11-07T13:17:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | CORREA, R. de S. et al. Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole. Journal of Inorganic Biochemistry, v. 156, p. 153-163, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0162013415301501>. Acesso em: 26 set. 2016. | pt_BR |
dc.identifier.issn | 0162-0134 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/7067 | - |
dc.description.abstract | Three newmixed and mononuclear Ru(II) complexes containing 1,3-thiazolidine-2-thione (tzdtH) were synthesized and characterized by spectroscopic analysis, molar conductivity, cyclic voltammetry, high-resolution electrospray ionization mass spectra and X-ray diffraction. The complexes presented unique stereochemistry and the proposed formulae are: [Ru(tzdt)(bipy)(dppb)]PF6 (1), cis-[Ru(tzdt)2(PPh3)2] (2) and trans- [Ru(tzdt)(PPh3)2(bipy)]PF6 (3), where dppb = 1,4-bis(diphenylphosphino)butane and bipy= 2,2′-bipyridine. These complexes demonstrated strong cytotoxicity against cancer cell lines when compared to cisplatin. Specifically, complex 2 was the most potent cytotoxic agent against MCF-7 breast cells, while complexes 1 and 3 were more active in DU-145 prostate cells. Binding of complexes to ctDNA was determined by UV–vis titration and viscosity measurements and revealed binding constant (Kb) values in range of 1.0–4.9 × 103 M−1, which are characteristic of compounds possessing weak affinity to ctDNA. In addition, these complexes presented antiparasitic activity against Trypanosoma cruzi. Specifically, complex 3 demonstrated strong potency, moderate selectivity index and acted in synergism with the approved antiparasitic drug, benznidazole. Additionally, complex 3 caused parasite cell death through a necrotic process. In conclusion, we demonstrated that Ru(II) complexes have powerful pharmacological activity, while the metal-free tzdtH does not provoke the same outcome. | pt_BR |
dc.language.iso | pt_BR | pt_BR |
dc.rights | aberto | pt_BR |
dc.subject | Cytotoxicity | pt_BR |
dc.subject | Trypanosoma cruzi | pt_BR |
dc.title | Ruthenium(II) complexes of 1,3-thiazolidine-2-thione : cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | O periódico Journal of Inorganic Biochemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3958741353996. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.jinorgbio.2015.12.024 | - |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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ARTIGO_RutheniumComplexesThiazolidine.pdf | 1,23 MB | Adobe PDF | Visualizar/Abrir |
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