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Title: Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis.
Authors: Silva, Luciano Bruno Carvalho
Oliveira, Maysa do Vale
Gontijo, Vanessa Silva
Oliveira, Williana Fernandes de
Derogis, Priscilla Bento Matos Cruz
Stringheta, Paulo César
Nagem, Tanus Jorge
Brigagão, Maísa R. P. L.
Santos, Marcelo Henrique dos
Keywords: Medicinal plants
Micronucleus test
Issue Date: 2012
Citation: SILVA, L. B. C. et al. Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis. Food Research International, v. 48, p. 180-186, 2012. Disponível em: <>. Acesso em: 19 fev. 2015.
Abstract: This paper describes the investigation of the cytotoxic and antioxidant activities and in vivo mutagenic/ antimutagenic potential of different concentrations of the hexane extract (EHP) and isolated molecule 7-epi-clusianone (MI) of Rheedia brasiliensis. The in vitro antioxidant activity of MI was investigated by monitoring the reduction of radical scavenging and metal chelating activity of DPPH (1,1-diphenyl-2-picrylhydrazil). Cytotoxic activity was assessed by measuring the mortality of brine shrimp in the presence and absence of the compounds. The mutagenic, antimutagenic and cytotoxic effects of these compounds were evaluated by a micronucleus test. During the antioxidant activity assessment, the 7-epi-clusianone was significantly higher than that of EHP at all concentrations in three assays. From the results obtained with the assessment of cytotoxic activity, all samples had a mortality rate (LC50b100 mg/mL) lower than the positive control (thymol). The results of the micronucleus test revealed that MI at 5, 10 and 15 mg/kg b.w. is antimutagenic. In conclusion, these results suggest that in the future, the EHP and MI could be used as prophylactic agents in cancer prevention.
ISSN: 0963-9969
metadata.dc.rights.license: O periódico Food Research International concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3582471067314.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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