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Title: Biological screening of extracts of Brazilian Asteraceae plants.
Authors: Carvalho, Cintia Cristina de
Machado, Kamilla Nunes
Ferreira, Paulo Michel Pinheiro
Pessoa, Cláudia
Fonseca, Thaisa Helena Silva
Gomes, Maria Aparecida
Nascimento, Andréa Mendes do
Keywords: Drug prospecting
Antiprotozoal agents
Drug screening assays
Brazilian plant
Issue Date: 2013
Citation: CARVALHO, C. C. de et al. Biological screening of extracts of Brazilian Asteraceae plants. African Journal of Pharmacy and Pharmacology, v. 7, p. 2000-2005, 2013. Disponível em: <>. Acesso em: 02 fev. 2015.
Abstract: Natural products are a very productive source of leads for the development of medicines. Seven Brazilian Asteraceae adult plants were randomly chosen. The current study was designed to evaluate the antiprotozoal and cytotoxic activities in vitro of 21 extracts obtained. Phytochemical properties of the most active extracts also were checked. Cytotoxic activity was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines (HCT-116, OVCAR 8 and SF-295). The antiprotozoal activity was evaluated against Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. None of the extracts showed antiprotozoal activity. However, 76% of the extracts displayed moderate to high in vitro cytotoxic activities against human cancer cell which suggests that they are a promising source of anticancer compound, since none of the extracts showed hemolytic activity. Terpenoids, flavonoids, saponins, tannins, besides other compound classes, were identified and may be responsible for their antitumor activity. Cytotoxic assays indicate the anticancer potential of Asteraceae species from Brazil.
ISSN: 1996-0816
metadata.dc.rights.license: This article is published under the terms of the Creative Commons Attribution License 4.0 that allows copy and redistribute the material in any medium or format. Fonte: African Journal of Pharmacy and Pharmacology <>. Acesso em: 25 fev. 2014.
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