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Title: Short-term protection conferred by Leishvacin® against experimental Leishmania amazonensis infection in C57BL/6 mice.
Authors: Carneiro, Matheus Batista Heitor
Sousa, Louisa Maria de Andrade e
Vaz, Leonardo Gomes
Santos, Liliane Martins dos
Vilela, Luciano
Souza, Carolina Carvalho de
Gonçalves, Ricardo
Tafuri, Wagner Luiz
Afonso, Luís Carlos Crocco
Côrtes, Denise Fonseca
Vieira, Leda Quercia
Keywords: Leishmania amazonensis
Issue Date: 2014
Citation: CARNEIRO, M. B. H. et al. Short-term protection conferred by Leishvacin® against experimental Leishmania amazonensis infection in C57BL/6 mice. Parasitology International, v. 63, p. 826-834, 2014. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: To date, there is no vaccine available against human leishmaniasis. Although some vaccination protocols can induce immunity in murine models, they fail to induce protection in humans. The reasons for that remain unclear. The aimof the present study was to characterize the changes in the pattern of the immune response during subcutaneous vaccination with Leishvacin® in mice. We also investigated whether IFN-γ and nitric oxide synthase are indispensable for the protection elicited by the vaccine. C57BL/6 WT vaccinated mice showed smaller lesions and fewer numbers of parasites in footpads until 8 weeks post-infection. Up to this time, they produced higher levels of IFN-γ, IL-2, IL-4, IL-17A and IL-10 and higher specific antibody response than control non-vaccinated mice. Moreover, we showed that IFN-γ, most likely by induction of iNOS expression, is essential for immunity. However, after 12 weeks of infection, we observed loss of difference in lesion size and parasite burden between the groups. Loss of resistancewas associatedwith the disappearance of differences in cytokine patterns between vaccinated and control mice, but not of antibody response, which remained different until a later time of infection. The reversal of resistance to L. amazonensis could not be explained by upregulation of regulatory cytokines. Our data point to a subversion of the host immune response by L. amazonensis even when a protective response was previously induced.
ISSN: 1383-5769
metadata.dc.rights.license: O periódico Parasitology International concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3525980520607.
Appears in Collections:DECBI - Artigos publicados em periódicos

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