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dc.contributor.authorLombana, Claudia Zuleida Gonzalez-
dc.contributor.authorSantiago, Helton da Costa-
dc.contributor.authorMacedo, J. P.-
dc.contributor.authorRego, Virgínia Aparecida Seixas-
dc.contributor.authorRusso, Remo de Castro-
dc.contributor.authorTafuri, Wagner Luiz-
dc.contributor.authorAfonso, Luís Carlos Crocco-
dc.contributor.authorVieira, Leda Quercia-
dc.identifier.citationLOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <>. Acesso em: 08 nov. 2014.pt_BR
dc.description.abstractExperimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis.pt_BR
dc.subjectProtozoan parasitespt_BR
dc.subjectCutaneous leishmaniasispt_BR
dc.subjectCellular recruitmentpt_BR
dc.titleEarly infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3525980735803.pt_BR
Appears in Collections:DECBI - Artigos publicados em periódicos

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