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http://www.repositorio.ufop.br/jspui/handle/123456789/14679
Título : | A new theranostic system for bone disorders : functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64. |
Autor : | Cipreste, Marcelo Fernandes Mussel, Wagner da Nova Silva, Juliana Batista da Marques, Maria Betânia de Freitas Batista, Ronaldo Junio Campos Gastelois, Pedro Lana Macedo, Waldemar Augusto de Almeida Sousa, Edésia Martins Barros de |
Palabras clave : | Medronate |
Fecha de publicación : | 2020 |
Citación : | CIPRESTE, M. F. et al. A new theranostic system for bone disorders: functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64. Materials Chemistry and Physics, v. 254, artigo 123265, 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0254058420306350>. Acesso em: 25 ago. 2021. |
Resumen : | Hydroxyapatite nanoparticles have been investigated as biological agents for the treatment and diagnosis of bone diseases due to their properties, providing high affinity to bone tissues and also due to the possibility to chemically modify the surfaces of these nanoparticles to provide active targeting to bone tumors or other bone disorders. In this work, synthetic hydroxyapatite nanoparticles and their surface modifications with folic and medronic acid were studied. Copper-64 was produced by neutron irradiation in a TRIGA MARK I nuclear reactor, and the functionalized nanoparticles radiolabeled with this radioisotope. The multi-technique characterization includes FTIR, PXRD, TGA, DSC, CHN, Zeta potential, XPS, SEM, TEM, and Gamma spectroscopy. Furthermore, the evaluation of the chemical interaction stability was through leaching tested for efficiency. The results indicate that folic and medronic acids can be covalently bonded to HA surface, producing a new material not yet described in the literature, been stably attached to hydroxyapatite nanoparticle surfaces, able to provide active targeting for bone disorders. The complexation of copper-64 provides high radiochemistry purity, although the specific activity must be improved. |
URI : | http://www.repositorio.ufop.br/jspui/handle/123456789/14679 |
metadata.dc.identifier.uri2: | https://www.sciencedirect.com/science/article/abs/pii/S0254058420306350 |
metadata.dc.identifier.doi: | https://doi.org/10.1016/j.matchemphys.2020.123265 |
ISSN : | 0254-0584 |
Aparece en las colecciones: | DEFIS - Artigos publicados em periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_NewTheranosticSystem.pdf Restricted Access | 13,89 MB | Adobe PDF | Visualizar/Abrir |
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