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Título : | Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
Autor : | Silva, Neide Maria Vieira, Júlio César Menezes Carneiro, Cláudia Martins Tafuri, Wagner Luiz |
Palabras clave : | Inflammation Protozoa Toxoplasma gondii |
Fecha de publicación : | 2009 |
Citación : | SILVA, N. M. et al. Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Experimental Parasitology, v. 123, n. 1, p. 65-72, set. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489409001490>. Acesso em: 19 set. 2012. |
Resumen : | In order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively. |
URI : | http://www.repositorio.ufop.br/handle/123456789/1398 |
ISSN : | 00144894 |
metadata.dc.rights.license: | O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420279890. |
Aparece en las colecciones: | DEACL - Artigos publicados em periódicos |
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Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_ToxoplasmaGondiiRole.pdf | 724,87 kB | Adobe PDF | Visualizar/Abrir |
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