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Title: Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection.
Authors: Silva, Neide Maria
Vieira, Júlio César Menezes
Carneiro, Cláudia Martins
Tafuri, Wagner Luiz
Keywords: Inflammation
Toxoplasma gondii
Issue Date: 2009
Citation: SILVA, N. M. et al. Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Experimental Parasitology, v. 123, n. 1, p. 65-72, set. 2009. Disponível em: <>. Acesso em: 19 set. 2012.
Abstract: In order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively.
ISSN: 00144894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420279890.
Appears in Collections:DEACL - Artigos publicados em periódicos

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