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Title: Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.
Authors: Bezerra, Frank Silva
Ramos, Camila de Oliveira
Castro, Thalles de Freitas
Araújo, Natália Pereira da Silva
Souza, Ana Beatriz Farias de
Bandeira, Ana Carla Balthar
Costa, Guilherme de Paula
Cartelle, Christiane Teixeira
Silva, André Talvani Pedrosa da
Cangussú, Silvia Dantas
Brochard, Laurent
Nagato, Akinori Cardozo
Keywords: BALB/c mice
Oxidative stress
Issue Date: 2019
Citation: BEZERRA, F. S. et al. Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice. Intensive Care Medicine Experimental, v. 7, p. 19,mar. 2019. Disponível em: <>. Acesso em: 10 fev. 2020.
Abstract: Background: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects during hyperoxia. Methods: Male BALB/c mice (8–10 weeks), a strain highly sensitive to hyperoxia, received the exogenous surfactant-containing protein SP-B and SP-C by intranasal instillation 12 h before starting 24 h of exposure to hyperoxia in an inhalation chamber and were compared to mice receiving hyperoxia alone and to controls subjected to normoxia. Results: Compared to the hyperoxia group, the administration of exogenous surfactante was able to reduce lung inflammation through a reduction in the influx of neutrophils and inflammatory biomarkers such as TNF, IL-17, and HMGB1 expression. The antioxidante activity prevented oxidative damage by reducing lipid peroxidation and protein carbonylation and increasing superoxide dismutase activity when compared to the hyperoxia group. Conclusion: Our results offer new perspectives on the effects and the mechanism of exogenous surfactant in protecting the airway and lungs, in oxygen-rich lung microenvironment, against oxidative damage and aggravation of acute inflammation induced by hyperoxia.
ISSN: 2197-425X
metadata.dc.rights.license: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Fonte: o próprio artigo.
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