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http://www.repositorio.ufop.br/jspui/handle/123456789/11972
Título: | Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. |
Autor(es): | Lopes, Ana Cristina dos Santos Perucci, Luiza Oliveira Evangelista, Fernanda Cristina Gontijo Godoi, Lara Carvalho Sabino, Adriano de Paula Gomes, Karina Braga Silva, André Talvani Pedrosa da Dusse, Luci Maria Sant'Ana Alpoim, Patrícia Nessralla |
Palavras-chave: | Preeclampsia Hypertension |
Data do documento: | 2019 |
Referência: | LOPES, A. C. S. et al. Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. Molecular and cellular probes, v. 45, p. 43-47, jun. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub>. Acesso em: 10 fev. 2020. |
Resumo: | Background: Genetic, immune and environmental factors are involved in preeclampsia (PE) etiopathogenesis. Considering that hypertension and poor placental perfusion are important features in PE, polymorphisms in the angiotensin-converting enzyme (ACE) and estrogen nuclear receptor 1 (ESR1) genes could be involved in the predisposition and/or development of the disease. The aim of this study was to evaluate if polymorphisms in ACE and ESR1 genes were associated with PE occurrence. Material and Methods: This case-control study included 209 Brazilian pregnant women (107 with severe PE and 102 normotensive controls). The polymorphisms were investigated by polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Results: No significant difference between PE versus normotensive pregnant women, as well as early versus late PE, was observed when compared the allelic and genotypic frequencies of insertion/deletion polymorphism in intron 16 of the ACE gene and the single nucleotide polymorphisms (SNPs - rs2234693 and rs9340799) of the ESR1 gene. Conclusion: This pioneer study involving Brazilian women showed no association among the studied polymorphisms and PE, which suggests that ins/del ACE and SNPs ESR1 do not contribute to this disease occurrence in Brazil. |
URI: | http://www.repositorio.ufop.br/handle/123456789/11972 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub |
DOI: | https://doi.org/10.1016/j.mcp.2019.04.004 |
ISSN: | 0890-8508 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_AssociationACEESR1.pdf Restricted Access | 514,6 kB | Adobe PDF | Visualizar/Abrir |
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